The Pocotaligo River is a tidal creek separating Beaufort and Jasper counties. The surrounding area served as the site of the Yamasee War of 1715 when members of the Yamasee tribe (now spelled Yemassee and pronounced YAM • uh • see) attacked colonial settlers. However, the English eventually dominated the Pocotaligo settlement and built a bridge over the creek, creating access between Charleston and nearby Savannah, Georgia.
Pocotaligo remained an important stop along this route through the decades, and a depot was built to provide railway access between these two major cities. In 1862 this railway became the site of a Civil War battle between the Federal troops who wanted to destroy it and the Confederate troops who succeeded in protecting it. Today the Pocotaligo River is a popular recreational site and frequented by kayakers.